14/02/2020
The Human Resources Strategy for Researchers

Ex vivo and in vivo gene replacement therapy for a severe genetic skin disease

This job offer has expired


  • ORGANISATION/COMPANY
    Institut Imagine/INSERM
  • RESEARCH FIELD
    Biological sciencesBiology
  • RESEARCHER PROFILE
    Established Researcher (R3)
    Recognised Researcher (R2)
  • APPLICATION DEADLINE
    30/04/2020 18:00 - Europe/London
  • LOCATION
    France › Paris
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    39
  • OFFER STARTING DATE
    30/04/2020

The laboratory is seeking for a post-doctoral researcher with an experience in molecular and cellular biology to develop ex vivo and in vivo replacement therapy for a severe genetic skin disease.

Benefits

The candidate will join an international research laboratory of 18 persons with a strong and long lasting expertise in genetic skin disorders, gene therapy, tissue engineering and in murine models of genetic skin diseases. He/she will have a unique opportunity to be trained in cutting edge technics in keratinocyte biology and gene replacement therapy. The laboratory is part of Imagine institute for genetic diseases located at Necker Hospital for sick children. The institute has a high performance plateforms in genomics, bioinformatics, cell imaging, flow cell sorting and animals models which could assist the applicant if necessary. The institute gathers research teams with complemntary expertises in multiples aspects of genetics, immunology, cell biology and bioinformatics. The institute is highly dynamic and will allow multiple interactions with leading scientist in gene therapy, immunology and human genetics.

Eligibility criteria

Candidates should have a PhD degree with a strong background in cell biology, and molecular biology

  • We are looking for a highly motovated scientist with a strong experience in molecular cloning and cellular biology.
  • A previous experience in gene therapy would be an advantage.
  • Priority will be given to candidates with an accreditation for animal experimentation (Level 1 or Level 2)
  • Good communication skills in oral and written English
  • Excellent organization skills
  • Ability to work in a team

The candidate should have been able to produce and show the functionality of a viral vector expressing the gene of interest in a 2-D culture system and in a xenograft skin equivalent model using patient primary keratinocytes.

Selection process

Please contact Alain HOVNANIAN including in the message a letter of motivation and a CV.

Web site for additional job details

Required Research Experiences

  • RESEARCH FIELD
    Biological sciences
  • YEARS OF RESEARCH EXPERIENCE
    1 - 4

Offer Requirements

  • REQUIRED LANGUAGES
    ENGLISH: Good

Skills/Qualifications

Candidates should have a PhD degree with a strong background in cell biology, and molecular biology

  • We are looking for a highly motovated scientist with a strong experience in molecular cloning and cellular biology.
  • A previous experience in gene therapy would be an advantage.
  • Priority will be given to candidates with an accreditation for animal experimentation (Level 1 or Level 2)
  • Good communication skills in oral and written English
  • Excellent organization skills
  • Ability to work in a team

Specific Requirements

He/she will be in charge of cloning and producing the viral vector and demonstrating functional correction using in vitro and in vivo models. In vitro models will involve the 2-D culture of human keratinocytes and 3-D skin equivalents. In vivo models will include a xenograft model of human skin equivalent grafted made from patient keratinocytes onto immunotolerant mice.

Work location(s)
1 position(s) available at
Institut Imagine/INSERM
France
Île-de-France
Paris
75015
24, boulevard Montparnasse

EURAXESS offer ID: 492649

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