Science 4 Refugees

PhD Position - Computational investigation of ion channels and transporters

    Forschungszentrum Jülich
    First Stage Researcher (R1)
    05/10/2020 19:07 - Europe/Brussels
    Germany › Jülich
    To be defined

Work group:

IBI-1 - Molekular- und Zellphysiologie

Area of research:

PHD Thesis

Job description:

Using a combination of molecular dynamics simulations, patch-clamp electrophysiology, and molecular biology, we investigate the structure–dynamics–function relationships of physiologically and clinically important membrane proteins. Furthermore, we study pathologic alterations of these proteins towards novel strategies to pharmacologically correct protein and cell function under disease conditions. The PhD project will focus on permeation and selectivity mechanisms in ion channels, functional mechanisms of ligand and voltage activation, or operational principles of thermodynamically coupled transporters relevant to brain function.

Your Job:

  • You will investigate ion channels or transporters using molecular dynamics simulations and collaborate with experimental electrophysiologists on a daily Basis
  • High-performance computing and use machine-learning techniques
  • Depending on your interest and experience, you may learn and conduct experiments (e.g. patch-clamp recordings) on your own

Your Profile:

  • Master’s degree in in physics, chemistry, biology, or any related subject
  • Strong interest the fields of biophysics and physiology, as well as in both computational and experimental methods to investigate membrane proteins
  • Knowledge of at least one programming language and basic experience with Unix-like operating systems are required
  • Experience in biochemical or biophysical methods, molecular modeling, or statistical mechanics will be a strong plus
  • Good communication skills in English are necessary

Our Offer:

  • Forschungszentrum Jülich is one of the largest interdisciplinary research centers in Europe, equipped with world-class computing resources at Jülich Supercomputing Centre
  • State-of-the-art methods to experimentally study ion channels and transporters
  • You will be part of German Research Foundation (DFG)-funded Research Units (FOR 2518: Functional dynamics of ion channels and transporters; FOR 5046: Integrated analysis of epithelial SLC26 anion transporters - from molecular structure to pathophysiology)
  • Applicants and successful candidates can also apply for membership in the International Helmholtz Research School of Biophysics and Soft Matter www.ihrs-biosoft.de that provides a complementary research training at the interfaces of biology, chemistry, and physics, as well as transferable skills courses
  • A dynamic and interdisciplinary research group with excellent computational and experimental equipment
  • A contract for the duration of 3 years
  • You will be employed at Forschungszentrum Jülich, but obtain your PhD degree at RWTH Aachen University
  • Participation in overarching seminars including certificate
  • Pay in line with 50 % of pay group 13 of the Collective Agreement for the Public Service (TVöD-Bund).
  • Information on employment as a PhD student at Forschungszentrum Jülich can be found here www.fz-juelich.de/gp/Careers_Docs

Forschungszentrum Jülich promotes equal opportunities and diversity in its employment relations.We also welcome applications from disabled persons.

Work location(s)
1 position(s) available at
Forschungszentrum Jülich

EURAXESS offer ID: 541269
Posting organisation offer ID: 2020D-077


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